以撒的结合原声音乐包合集是同名游戏的ost背景音乐集锦，官方发布的音乐包。以撒的结合是一款steam上的复古风格冒险游戏。

1. Those Responsible 00:13
 2. In The Beginning... 02:21 
 3. The Binding of Isaac 03:17  
 4. Unknown Depths Below 00:05  
 5. Sacrificial 05:08  
 6. Conflicted 00:08  
 7. Divine Combat 02:27  
 8. Pride 00:07  
 9. Peace Be With You 02:10  
 10. Agony 00:12  
 11. Repentant 05:22  
 12. Respite 02:04  
 13. $4cR1f1c14|_ 05:01  
 14. Dreadful 05:02  
 15. Burning Ambush 02:23  
 16. Greed 02:43  
 17. Thine Wrath... 03:15  
 18. Apostate 05:08  
 19. Hereafter 01:30  
 20. Temptation 02:14  
 21. The Pact 00:07  
 22. ...Be Done 02:01  
 23. Absolution 00:46  
 24. Ultimate Reward 00:13  
 25. End Times 01:54  
 26. In The Beginning... (No Voiceover) 02:21  
 27. Big Giant Circles - The Clubbing of Isaac (Remix) (free) 03:53 
 28. C418 - Atempause (free) 02:03